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| Market | Platform | Price |
|---|---|---|
![]() | Poly | 14% |
Trader mode: Actionable analysis for identifying opportunities and edge
This market will resolve to "Yes" if the CDC issues a Level 4 (“Avoid All Travel”) Travel Health Notice for any disease by December 31, 2026, 11:59 PM ET. Otherwise, this market will resolve to "No". A Level 4 notice listed for any amount of time during this market’s timeframe will suffice for a "Yes" resolution. The primary resolution source for this market will be the CDC’s official Travel Health Notices page (https://wwwnc.cdc.gov/travel/notices); however, a consensus of credible reporting
Prediction markets currently give about a 1 in 7 chance that the U.S. Centers for Disease Control and Prevention (CDC) will issue its most severe “Level 4: Avoid All Travel” warning for any disease by the end of 2026. This means traders collectively see it as unlikely, but not impossible. A Level 4 notice is the CDC’s highest alert, reserved for situations where travel poses an extreme health risk, often due to widespread disease outbreaks that could overwhelm local medical systems or involve novel, dangerous pathogens.
The low probability stems from a few factors. First, the CDC uses this top tier sparingly. During the COVID-19 pandemic, Level 4 warnings were common, but for a known, endemic disease to trigger one requires a severe and unexpected turn. Second, the long timeframe until December 2026 allows for potential new pathogens to emerge, which keeps the probability from being zero. However, the baseline expectation is that the world will not face a pandemic-scale threat in the next two years severe enough to warrant a blanket “avoid all travel” order for a country or region. The market is essentially betting that the current post-pandemic period will remain relatively stable in terms of explosive, novel outbreaks.
There is no single scheduled event for this prediction. Instead, traders will watch for unexpected viral outbreaks reported by global health bodies like the World Health Organization. A key signal would be the WHO declaring a Public Health Emergency of International Concern (PHEIC) for a new or re-emerging disease with high fatality rates and evidence of efficient human transmission. Seasonal patterns also matter; surges of diseases like avian influenza or a new coronavirus variant during fall or winter could shift the odds.
Prediction markets have a mixed record on rare, high-impact events like pandemics. They are often good at aggregating known information about institutional behavior, like the CDC’s cautious use of top-tier warnings. However, they can be slow to price in truly novel, “black swan” biological threats that appear with little warning. The 14% probability likely reflects the known historical rarity of Level 4 notices outside of extreme circumstances, but it may not fully capture the inherent uncertainty of global health over a multi-year period.
The Polymarket contract "CDC issues Level 4 warning by December 31?" is trading at 14¢, indicating a 14% probability. This price suggests the market views the event as unlikely within the timeframe, which extends to December 31, 2026. With only $44,000 in total volume, liquidity is thin. This low volume can amplify price swings and means the current odds may not reflect a deep consensus.
The low probability is anchored in the CDC's historical use of Level 4 warnings. These are reserved for extreme scenarios involving widespread, uncontrolled disease transmission with severe health risks and breakdowns in healthcare infrastructure. The last Level 4 notices were issued during the peak of the COVID-19 pandemic in 2020 and 2021. Since then, the CDC has not elevated any threat to Level 4, even for significant outbreaks like the global mpox surge in 2022 or regional dengue fever epidemics. The market is pricing in a continuation of this post-pandemic baseline, where major threats are managed with lower-level advisories.
A second factor is the extended timeframe. A 14% chance over nearly two years is not trivial. It acknowledges the persistent threat of novel pathogens or a sudden, severe turn in an existing epidemic. The ongoing spread of H5N1 avian flu in animal populations is a known wild card that could trigger a reassessment if human-to-human transmission is confirmed.
The primary catalyst for a dramatic price increase would be the emergence of a novel pathogen with high mortality and clear evidence of efficient human transmission. A mutation in the H5N1 virus that facilitates sustained human spread would almost certainly force the CDC's hand. Similarly, a large-scale outbreak of a disease like Crimean-Congo hemorrhagic fever or a new SARS-like virus in a region with heavy travel links could prompt a Level 4 designation.
Conversely, the odds could fall further if the next 12-18 months pass without a major global health scare. Each quarter without a significant epidemic reinforces the market's view that the post-COVID period is one of heightened surveillance and containment, reducing the need for the most severe travel warnings. Monitoring CDC updates for any Level 3 ("Reconsider Travel") advisories is key, as an escalation from Level 3 to Level 4 would be a clear signal.
AI-generated analysis based on market data. Not financial advice.
$43.56K
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This prediction market asks whether the U.S. Centers for Disease Control and Prevention (CDC) will issue its highest-level travel health advisory, a Level 4 'Avoid All Travel' notice, for any disease by December 31, 2026. The CDC's Travel Health Notices are formal recommendations advising U.S. travelers on health risks abroad. A Level 4 notice is the most severe, indicating an extreme health risk that warrants avoiding all travel to a destination. The market resolves based on the official CDC Travel Health Notices page, with any Level 4 notice posted for any duration during the timeframe resulting in a 'Yes' outcome. This topic sits at the intersection of global public health, international travel, and governmental risk communication. Interest stems from the potential for a major disease outbreak to trigger such a severe advisory, which has significant economic and diplomatic consequences. The market timeframe, ending in late 2026, allows for monitoring of emerging infectious disease threats, including novel pathogens, resurgent familiar diseases, or escalating outbreaks of ongoing concerns like avian influenza or mpox. Observers track epidemiological data, World Health Organization alerts, and geopolitical instability in regions with weak health systems as potential precursors to a CDC Level 4 declaration.
The CDC's Travel Health Notice system has existed for decades, but its use and public prominence increased dramatically during the 2014-2016 Ebola virus epidemic in West Africa. The CDC issued a Level 3 'Avoid Nonessential Travel' notice for Guinea, Liberia, and Sierra Leone, stopping short of Level 4. The COVID-19 pandemic marked a watershed moment for the system. In early 2020, the CDC rapidly escalated warnings for China and other countries, though it initially used Level 3 notices broadly. A clear precedent for a Level 4 notice due to infectious disease is the warning for Venezuela in March 2019. The CDC issued a 'Level 4 - Avoid All Travel' notice due to the complete collapse of the country's healthcare system, outbreaks of measles and diphtheria, and the inability of hospitals to provide care. This established that a systemic health infrastructure failure, not just a single disease outbreak, could trigger the highest warning. Prior to the pandemic, Level 4 notices were more commonly associated with non-infectious risks like armed conflict or natural disasters. The system's evolution shows an increasing willingness to use the highest warning for public health crises.
A CDC Level 4 travel warning has immediate and severe economic consequences. It triggers travel insurance nullifications, leads airlines to cancel flights, and causes cruise lines to reroute itineraries. The tourism and hospitality industries in the affected country face catastrophic losses. For the United States, it can strain diplomatic relations, as foreign governments often perceive the advisories as damaging and politically motivated assessments of their public health capabilities. For global health, a Level 4 notice signals a loss of confidence in a country's ability to manage a health crisis, potentially isolating it and hindering international aid coordination. The notice affects millions of people: U.S. citizens advised against travel, families with relatives in the affected region, businesses with operations there, and global supply chains that rely on movement of personnel. A resolution of 'Yes' in this market would indicate a major, uncontrolled disease event occurring somewhere in the world between now and 2026, with ramifications far beyond travel plans.
As of late 2024, no CDC Level 4 Travel Health Notices are active for an infectious disease outbreak. The longstanding Level 4 notice for Venezuela remains, but it is attributed to a healthcare system collapse rather than a single, acute outbreak. The global public health landscape is monitoring several potential threats. These include ongoing H5N1 avian influenza outbreaks in poultry and cattle across multiple countries, with sporadic human cases, and persistent mpox (formerly monkeypox) outbreaks in the Democratic Republic of the Congo. The CDC has not elevated its travel advice for these situations to Level 4. The agency's current public focus is on routine travel health guidance and preparedness for potential seasonal respiratory virus surges.
The CDC's Travel Health Notices warn specifically about health risks like disease outbreaks. The U.S. State Department's Travel Advisories warn about overall safety risks like terrorism, crime, or civil unrest. Both use a four-level scale, but they assess different threats. A destination can have a high-level warning from one agency but not the other.
No. During the COVID-19 pandemic, the CDC issued widespread Level 3 ('Avoid Nonessential Travel') warnings for most of the world. It did not escalate any country to Level 4 specifically for COVID-19. This historical precedent is important for assessing the high bar required for a Level 4 designation.
The CDC typically issues Travel Health Notices for entire countries. In rare cases, it may specify a particular region within a country if the health threat is highly localized, but the notice itself is still listed under the country's name. The resolution criteria for this market would be met if any geographic designation receives a Level 4 notice.
Diseases with high fatality rates, no effective treatments or vaccines, and potential for rapid international spread are the most likely candidates. Historical examples that prompted serious advisories include Ebola, SARS, and pandemic influenza. A novel pathogen with these characteristics would pose the highest risk for a Level 4 warning.
The CDC can issue a new notice or change a level within 24-48 hours of a major WHO declaration or internal risk assessment. Removing a notice, especially Level 3 or 4, takes much longer. It requires sustained evidence that the threat has diminished, often taking months or years, as seen with the Venezuela notice.
Educational content is AI-generated and sourced from Wikipedia. It should not be considered financial advice.

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